Histopathological studies on the curative role of Mentha longifolia in Trypanosoma evansi experimentally infected rats

نویسندگان

چکیده

Trypanosomiasis is an important protozoan disease of domestic animals and man. One the pathogenic trypanosomes in Trypanosoma evansi; causative agent Surra that highly fatal to a number domesticated mammals such as camels. Mentha longifolia plant has been used traditional medicine treat some parasitic microbial diseases different countries. This study was conducted evaluate antitrypanosomal activity leaf ethanolic extract M. against experimentally induced T. evansi infection rats. A total 16 male albino rats were allocated into four groups each; uninfected control group (CG), (PG), trypanosome infected  (TG), infected treated (plant + trypanosome) (PTG). Blood tissue samples collected from on 35th day after treatment. Hematological results obtained evansi-infected showed microcytic hypochromic anemia with significance (P< 0.05). There significant 0.05) increase leukocytic count (TLC) neutrophils, eosinophils, monocytes TG) compared those CG, PG, PTG. Histopathological examination revealed necrosis, hydropic degeneration liver apoptosis, hemorrhage, edema, inflammatory cell infiltration kidney, demyelination brain, lymphocytic granuloma lung. Results present not effective vivo, despite its high vitro.

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ژورنال

عنوان ژورنال: Journal of Veterinary Medical Research

سال: 2021

ISSN: ['2357-0520', '2357-0512']

DOI: https://doi.org/10.21608/jvmr.2021.61380.1033